Systems Biology and Biomechanical Model of Heart Failure
نویسندگان
چکیده
منابع مشابه
Systems Biology and Biomechanical Model of Heart Failure
Heart failure is seen as a complex disease caused by a combination of a mechanical disorder, cardiac remodeling and neurohormonal activation. To define heart failure the systems biology approach integrates genes and molecules, interprets the relationship of the molecular networks with modular functional units, and explains the interaction between mechanical dysfunction and cardiac remodeling. T...
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Heart failure with normal ejection fraction (HFNEF) is currently the most prevalent clinical phenotype of heart failure. However, the treatments available have shown no reduction in mortality so far. Advances in the omics sciences and techniques of high data processing used in molecular biology have enabled the development of an integrating approach to HFNEF based on systems biology. This study...
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Despite repeated attempts to develop a unifying hypothesis that explains the clinical syndrome of heart failure, no single conceptual paradigm for heart failure has withstood the test of time. Whereas clinicians initially viewed heart failure as a problem of excessive salt and water retention that was caused by abnormalities of renal blood flow (the “cardiorenal model”1), as physicians began to...
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Background: Depression and anxiety are highly prevalent in heart failure patients and has been associated with adverse prognosis, reduced functional ability and greater use of health care resources. Aim: To determine the effect of using partnership care model on anxiety and depression in heart failure patients. Method: This clinical trial was conducted as quasi-experimental design on 90 patient...
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ژورنال
عنوان ژورنال: Current Cardiology Reviews
سال: 2012
ISSN: 1573-403X
DOI: 10.2174/157340312803217238